Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out?

Abstract The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic fibrinolytic equilibrium. mainstay treatment these complications involves use antithrombotic agents but despite advances pharmacotherapy, there remains a significant proportion patients who continue to remain at risk. Endogenous fibrinolysis is physiological counter-measure against lasting thrombosis may be measured using several techniques identify higher risk benefit from more aggressive pharmacotherapy. However, assessment system not yet accepted into routine clinical practice. In this review, we will revisit different methods assessing endogenous (factorial assays, turbidimetric lysis viscoelastic global tests), including strengths, limitations, correlation outcomes each method how might integrate practice future.